Evidence Mounts Linking Fractures to Diabetes Drugs
By Mike Boyle

The popular diabetes drugs Actos and Avandia are in the news again, as a new study echoing previous research shows the drugs boost the risk of fractures in older women.

In the study, published online in the Journal of Clinical Endocrinology & Metabolism, William H. Herman, MD, MPH, professor of medicine and epidemiology at the University of Michigan, Ann Arbor, evaluated a large database of managed care patients who had diabetes. He found that those who suffered fractures were more likely to be taking the class of drugs known as TZDs (thiazolidinediones), such as Actos and Avandia, reports WebMD.

Herman told WebMD that the fracture risk he found was primarily among postmenopausal women, who already tend to have lower bone density. "Diabetic women over 50 with fractures were 70% more likely to be taking a TZD drug than women without fractures," he says.

Read much more of WebMD`s coverage here, plus take a look at an abstract of the actual study here.


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Originally posted by DiabetesCare.net on August 2, 2010.